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KMID : 0616120210520010019
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 1 p.19 ~ p.25
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Neuroprotective Activity of Lonicerin Isolated from Lonicera japonica
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Lee Hyun-Woo
Ma Choong-Je
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Abstract
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We previously reported that lonicerin isolated from Lonicera japonica methanolic extract had potent neuroprotective activities in neuronal cell death injured by excessive glutamate. In this study, we tried to confirm the neuroprotective activities of L. japonica extract and lonicerin in glutamate injured HT22 cells and establish mechanisms of neuroprotective action of lonicerin. We used HT22 cell death injured by glutamate as a bioassay system. The compound decreased reactive oxygen species increased by excessive glutamate treatment in HT22 cells. Also, Ca2+ concentration was decreased by lonicerin treatment. This compound made mitochondrial membrane potential maintain to normal condition. Lonicerin also increased not only glutathione reductase but also peroxidase to the control level. And this compound increased amount of glutathione, an endogenous antioxidant. These results indicated that lonicerin isolated from L. japonica showed potent neuroprotective activity through the anti-oxidative pathway.
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KEYWORD
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Lonicera japonica, Lonicerin, Neuroprotection, Antioxidant, Alzheimer’s disease
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